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* Correspondence: Meiying Jin, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For patients without insurance coverage, they can be a practical first line, particularly when paired with a reduced calorie diet and regular exercise

Major caution: The biggest risk is systemic toxicity (CNS and cardiac effects) if too much drug is absorbed

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These receptors are not only located in the pancreas but also in brain reward centers and modulate appetite and impulse

[8] A review and meta-analysis in 2009 found the benefits of its use inconclusive