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This is different from GLP-1s mechanism, which primarily reduces the drive to eat and the reward value of food through hypothalamic and mesolimbic circuits
Should be used with caution in patients with a history of gastrointestinal disorders, as it may exacerbate symptoms
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This study provides evidence that OB GLP-1 signalling engages a top-down neural mechanism to control insulin secretion via the SNS
This is where precision dosing becomes essential for safety and efficacy
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