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One way this is done is through conjugation with GST (glutathione S-transferase) enzymes

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Arch Pharm 358(1):e2400702 Thabet NM, Abdel-Rafei MK, Askar MA et al (2023) Nanocomposite zinc oxide@ -linolenic acid-canagliflozin-fucoxanthin and/or -radiation perturbs key metabolic effectors and suppresses the proliferation of breast cancer cells in vitro

We keep a close eye on how patients react to treatment and adjust the dose as needed