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Most users experience mild or no side effects, though injection-site reactions, nausea, dizziness, and headache occur in a subset of patientstypically at rates below 10% in observational data

However, body composition changes from successful fat loss can affect insulin sensitivity independently

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In Denmark, however, patients receive injections of 1 mg cyanocobalamin per week during the first month and every 3 months after that, or 1 mg hydroxycobalamin every other month.

Three RCTs met inclusion criteria The trials randomized 153 participants (74 participants to oral vitamin B12 and 79 participants to IM vitamin B 12 )