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Clinical Significance: These data suggest that orforglipron could provide an oral alternative to injectable GLP-1 therapies

Injection site reactions such as pain, itching, irritation, bruising, or redness

However, semaglutide can influence certain blood test resultsincluding glucose, HbA1c, and lipid levelsdue to its therapeutic effects

Over 50% of the population is overweight and could potentially be indicated for these weight loss agents

Ipamorelin mimics ghrelin and has a strong effect on growth hormone (GH) and insulin-like growth factor 1 (IGF-1)

So it was a kind of off-target observation when it was used for individuals with diabetes to then start studying it for obesity