59 Concerns were also raised about a possible link between the rare medullary thyroid carcinoma (MTC) and the use of the agents discussed in this article
A double reciprocal replot of k obs versus [I] did not fit to a linear relationship (unpublished data)

A 2021 review published in Biomedicine & Pharmacotherapy explains that silymarin, the main active compound in milk thistle, can:25 Regulate the cell cycle, helping to ensure proper division and replication Induce apoptosis, or programmed cell death, by which the body can eliminate mutated cells (e.g., cancer cells) Regulate the body's immune response, increasing its ability to recognize and attack cancer cells Keep tumor cells from growing and spreading Inhibit angiogenesis, the process by which tumors create new blood vessels that increase their blood supply and help them grow The review specifically discusses silymarin's therapeutic potential for gastrointestinal cancer, but as another set of researchers note, silymarin has a pleiotropic effect, meaning it can act on multiple targets.26 Again, more research may be needed, but the current science suggests that milk thistle may have fairly broad complementary utility in cancer therapy

These medications work by mimicking the hormone GLP-1 to reduce appetite, slow gastric emptying, and improve insulin sensitivity
10.3390/ijms18051018 Int
Full text Sanyal AJ, et al