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The mechanism is multifactorial: fibroblast activation, matrix-protein modulation, and inflammatory damping

Lower mortality risk in those with ischemic myocardial infarction, or heart attack

Regulatory agencies continue to evaluate findings, and prospective mothers using these medications are often advised to discontinue their use before conception or as soon as pregnancy is confirmed

FDA-approved medications offer predictable effectiveness, known dosing ranges, established titration schedules, and clear safety profiles

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