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PMID: 27977392

The 2017 Hsieh paper documented receptor activation and upregulation in vascular endothelium (PMID 27847966)

By contrast, variants from higher-stringency campaigns (X(PC2)aX(PC2)e) evolved strong activity on procaspase-1, maintained activity on VAMP1 but lost activity on PC_SS1 (Extended Data Fig

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