In between-drug comparisons, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 4.60 kg [95% CI 7.94, 1.26]), 1.0 mg (MD = 3.53 kg [95% CI 4.80, 2.25]) and 0.5 mg (MD = 2.75 kg [95% CI 4.23, 1.28]), respectively (ESM Table 11)
A high-quality insulated cooler with multiple gel packs can maintain temperature for 24 to 48 hours if you keep it sealed, in the shade, and away from heat sources
For semaglutide it flags personal or family history of medullary thyroid cancer and multiple endocrine neoplasia type 2 instead, and asks that kidney function, thyroid history, and gastric tolerance all be assessed first
In recent years, there has been more light shed on multiple cases of vision impairment linked to weight loss medications
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Always check your vial concentration before converting