The cornerstone of management involves both pharmacological strategies and practical lifestyle modifications that work synergistically to minimise gastrointestinal disturbance
These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics that act as incretin mimetics, targeting G-proteincoupled receptors such as GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are crucial in body fat and energy balance regulation
Overactivation of the ECS has been described in multiple pathologies including type 2 diabetes [5, 41, 42], for which blockade of CB1R has been explored as a therapeutic strategy [43]
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Or explore microdosing tirzepatide as a way to maintain the same medication at a dose your body tolerates better, though this sacrifices some effectiveness
Need for maintenance dose: Need Of Maintenance Dose-Picture Courtesy: Health Cleveland Clinic Initially you administer dose every week for almost 6 weeks