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Nonetheless, in very high doses, it can cause an intense acne flare-up

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Previous studies have shown that the CpG-rich promoter region of the -class gene GSTP1 is methylated at single restriction sites in the majority of prostate cancers

Increases in blood vessel constriction by COX-2 inhibition can also lead to the hypertension and renal failure seen in some studies of non-selective and COX-2 selective NSAIDs (Conaghan 2012)

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