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Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity
In some cases, diagnostic testing such as upper gastrointestinal imaging or gastric emptying studies may be appropriate to assess gastric function
In Canada, Zepbound is approved as a long-term treatment for adults with obesity (BMI 30), or those who are overweight (BMI 27) and living with at least one weight-related health condition (including hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease)
If domperidone is considered, it should only be used at the lowest effective dose for the shortest possible duration (usually no more than 7 days) due to cardiac safety concerns, and is contraindicated in people with certain heart conditions or those taking medications that affect heart rhythm
Doctors believe that semaglutide does not directly weaken the lower esophageal sphincter (LES), which is the muscle that prevents stomach acid from coming up
Your GP should assess metabolic risk factors, perform non-invasive fibrosis testing (FIB-4 or NAFLD Fibrosis Score), and refer you to a hepatologist if advanced fibrosis is suspected or liver function tests remain persistently abnormal
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