Oral Supplements: A Quick Comparison For people with a confirmed deficiency, especially those with absorption problems, injections generally act faster than oral supplements: Injections: bypass the gut, reliably reach the bloodstream, and often produce noticeable changes in energy and mental clarity within days for those who are deficient
By comparison, oral B12 supplements are absorbed at roughly 1 to 5% in healthy adults, and even less if you have low intrinsic factor, atrophic gastritis, celiac disease, Crohn's, or a history of gastric bypass
Physical signs
B-12 injections bypass the digestive system entirely
Vitamin B 12 is crucial for neurologic function, red blood cell production, and DNA synthesis, and is a cofactor for three major reactions: the conversion of methylmalonic acid to succinyl coenzyme A
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