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Before starting a patient on a GLP-1 medication, I emphasize that these are long-term medications to treat the chronic disease of obesity and prevent future complications

First came GLP-1 receptor agonists, then dual agonists targeting two hormonal axes, and now GLP-3s like retatrutide

For patients with MCAS specifically, what piqued my interest in giving this class of medications a try was a case series in The American Journal of the Medical Sciences from mast cell experts, including doctors Afrin, Weinstock and Dempsey

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