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ML algorithms, such as convolutional neural networks (CNNs), random forests, and ensemble methods, are increasingly applied to neuroimaging data from large consortia like the Alzheimers Disease Neuroimaging Initiative (ADNI)

However, the position of the cytoplasmic end of TM6 in the inactive state (either antagonist-bound or apo without G protein) structures is incompatible with the insertion of the C-terminus of GH5 (Fig

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