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Bilateral NGs were collected, embedded in Tissue-Tek O.C.T

The increased inositol-requiring enzyme 1 expression by PFOS, which indicated endoplasmic reticulum (ER) stress activation, was associated with PFOS-mediated autophagy activation that could be attenuated through 4-phenylbutyrate (5 mM, an ER stress inhibitor) and l-Carnitine pretreatment

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All four PDK have been shown to be able to phosphorylate sites 1 and 2