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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

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B., & Seghinsara, A

A proteolysis-resistant MRI-visible nanoparticle formulation of GLP-1RA (nano-GLP-1RA) was engineered to target GLP-1Rexpressing cells within atherosclerotic lesions ( In ApoE/ mice, nano-GLP-1RA selectively accumulated in plaque-resident inflammatory and de-differentiated smooth muscle cells, consistent with GLP-1Rexpressing populations observed in human plaques ( Taken together, while imaging and omics technologies offer powerful tools to characterize vascular biology, their integration with GLP-1RA therapy for patient stratification remains an emerging concept that requires further clinical validation

Men are also more likely to develop conditions associated with reduced glutathione or higher oxidative stress, including, More visceral fat than women, which drives insulin resistance 49 Higher rates of sleep apnea, another contributor to oxidative stress 50 Cardiovascular disease, which occurs about 710 years earlier in men than in women on average 51 As estrogen declines through perimenopause and menopause for womenand remains lower in men overalldifferences in glutathione activity likely reflect hormonal influence as much as sex-based biology, Tennant says

While the exact mechanisms remain unclear, these pathways are thought to play a role in appetite regulation and energy balance