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confirmed that in MCF-7 cells, which a low aggressive breast cancer cell line, the expression of GPx2 can be substantially up-regulated by retinoic acid [94]
However, unbinding of the product was calculated to be ~7 kcal mol -1 more favorable than the reactant, ensuring catalytic turnover
These hypotheses have sprung from its perceived potential to stimulate the production of collagen, elastin, and glycosaminoglycans, crucial intercellular matrix components
When GSH, the naturally more abundant form, encounters free radicalsincluding singlet oxygen, hydroxyl radicals, and superoxide radicals, all of which have the potential to damage cells and tissuesit can be oxidized to GSSG
This may be because of differences in the droplet dynamics of each UBQLN
