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Visible changes in tone and firmness appear at 4 to 8 weeks
The gene encoding the enzyme (symbol: GULO) is present in the human genome but it lacks five of the twelve exons required to make a functional protein
Eur J Biochem
2022
Safety Profile and Known Risks Water Retention and Joint Discomfort The most commonly reported adverse effects of GH-stimulating peptides are mild fluid retention and transient joint aching, consistent with the known side-effect profile of recombinant human GH (rhGH) therapy
Some researchers hypothesize potential complementary use, though this remains unstudied
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