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However, challenges remain in optimizing their therapeutic use, particularly due to low oral bioavailability and the complexity of their metabolic pathways
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This is done to manage potential side effects (like water retention) and to optimize cost
Eur J Endocrinol (2012) 168(1):913.10.1530/EJE-12-0457 63 FougnerSLBollerslevJLatifFHaldJKLundTRamm-PettersenJet alLow levels of raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment
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34,39,177 The rise in cAMP activates protein kinase A (PKA), which then promotes the synthesis and secretion of insulin and inhibits the release of glucagon
