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Inhibiting the enzyme is therefore investigated as a route to preserving both methyl donor pools and NAD+ availability, with downstream effects on sirtuin-dependent signaling
Everything else is shared, a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, norleucine at position 4 in place of the oxidation-prone methionine of the native hormone, and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core
M., Lingvay, I., Kahn, S
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