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Resources 1

To further verify that the catalytic activity of LOXL2 was responsible for the increase in BHZ signal, we used the following negative controls: (1) the overexpression of catalytically inactive H626/628Q LOXL2 double mutant (LOXL2-DM) 39,40 , (2) inhibition of LOXL2 specific activity using the small molecule inhibitor PAT-1251 (10 M) in cells overexpressing catalytically active LOXL2 41 , and (3) inhibition of total LOX activity using the non-selective small molecule LOX inhibitor -Aminopropionitrile (BAPN

& Horsley, V

Supplements support your health but do not replace a balanced diet

But it's also a convenient explanation that can lead people to persist with a protocol that's causing genuine harm

The strongest interpretation is that formulation, route, condition, and study design determine how much confidence a claim deserves