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However, numerous studies have shown that, aside from its anti-protease properties, AAT has anti-inflammatory and immune regulatory functions, and some of these functions seem to be independent of the anti-protease activities

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Ex-4 modulates apoptotic pathways in the hippocampus through the regulation of the expression levels of Bcl2, Bax, and caspase-3 [71], and it improves mitochondrial function and integrity in AD mice through the PI3K/Akt signaling pathway [72]

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The mice also showed signs of GLP-1 resistance: elevated levels of GLP-1 that did not help regulate blood sugar