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GLP-1s Are Getting Close to Surgery for Weight Loss Results Even with GLP-1 agonists being fairly new to the market, they continue to improve.We had some older drugs, phentermine and one called Qsymia, which is a combination of phentermine and topiramate, which got up to around 10% total body weight loss. When Wegovy and high-dose semaglutide were approved in 2021, thats when we started seeing around 15% total body weight loss

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Semaglutide should be avoided if Individuals suffering from pre-existing health conditions such as pancreatitis, decreased kidney function, low blood sugar, multiple endocrine neoplasia type 2, gallbladder disease, and diabetic retinopathy

Neuropeptides1992 Mar;21(3):143-6

But they didnt go above their baselines