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Finally, medications that can affect your period include: Hormonal birth control, which can cause breakthrough bleeding Copper intrauterine devices (IUD), which are nonhormonal but can cause heavy periods during the first year you use them Blood thinners and aspirin, which can cause heavier bleeding What Symptoms to Track If youre noticing period changes on semaglutide, tirzepatide, or other GLP-1s, it can be helpful to create a symptom tracking checklist

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