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In contrast to rAmy, Cagri primarily engages the CTR in a bypass conformation, equivalent to that observed when bound to AMYRs, with 85% of particles in the final particle stack stabilised in this conformation (Fig
However, in these cases, the excess glutamate comes from within the brain itself, not from the diet. There is no evidence of brain damage in humans resulting from dietary glutamate. Bottom line: Glutamate in the brain is synthesized in the brain
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Conventional L-amino acid peptides of this size are degraded within minutes by serum proteases
