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Some patients on GLP-1 medications notice they feel calmer or less driven by food cravings

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However, the effects of acute peripheral liraglutide are preserved in 5-HT 2C receptor KO mice [111], again suggesting different central pathways are targeted by endogenous GLP-1 and GLP-1R agonists

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Although all of the above-mentioned studies combined GLP-1 therapy with some form of lifestyle counselling, in each case the latter was described as standardised and infrequent, and can therefore be assumed to have been very much secondary to the medication