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Structural optimization: Further reduce IGFBP binding ability through site directed mutagenesis, or introduce transmembrane peptides to enhance tissue penetration
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In the context of GLP-1 receptor biology, where chronic high-level receptor activation can lead to tachyphylaxis (reduced responsiveness over time), partial agonism could potentially maintain a more sustained therapeutic effect over extended treatment periods
Fumarate L-Arginine 30 1-2 /
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