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However, considerable evidence exists on approaches to prevent muscle loss due to aging or weight loss induced by calorie restriction or bariatric surgery
Importantly, symptomatic toxicity generally doesn't occur until levels exceed approximately 2.0 mmol/L
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The feedback loop can be seen in Fig
6.4 TMAO and type 2 diabetes Clinical studies consistently link higher serum TMAO to T2DM compared to prediabetes or controls (146)
Lancet Neurol 14(3):329340 Biessels GJ, Verhagen C, Janssen J et al (2019) Effect of linagliptin on cognitive performance in patients with type 2 diabetes and cardiorenal comorbidities: the CARMELINA randomized trial
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