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It also means the dosing window is more flexible than peptides that require precise timing around growth hormone release patterns

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer

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doi:10.1016/S0736-0266(03)00110-4

IGF-1 LR3 retains the ability to bind IGF-1 and insulin receptors but has reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)