In the phase 2 trial published in the New England Journal of Medicine, participants on the 12mg dose saw liver fat reductions of up to 82.4%
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Clinical trials demonstrate: Weeks 14 : Minimal weight loss as your body adjusts Months 23 : More noticeable weight reduction as dose escalation continues Months 46 : Steady, consistent weight loss Peak effect : Maximum weight loss typically occurs at 6068 weeks of continuous treatment [15] According to FDA-approved labeling, patients on Wegovy (2.4 mg weekly) lost an average of 15% of their body weight over 68 weeks in clinical trials (STEP 1)
Niacin is not lost during the cooking process, unlike other B group vitamins
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However, long-term data on the specific four-peptide combination is limited