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The technology rapidly progressed with several types of co-agonists forging ahead in clinical trials including GIP/GLP-1 receptor dual agonists with one of the most notable being tirzepatide [8,9]

GLP-1 medications work by stimulating the release of insulin in response to high blood sugar, suppressing glucagon release, and slowing gastric emptying

While further behind alcohol and nicotine research, preliminary studies are examining whether GLP-1 agonists could complement existing treatments like buprenorphine and naltrexone for opioid use disorder

Starting GLP-1 after hormones are optimized may produce a stronger appetite-suppressing effect from the first dose

More serious but less common concerns have emerged regarding potential effects on various organ systems, including the gallbladder

Studies are also underway for a spectrum of other conditions, including Phase 3 trials investigating non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA), as well as mid-to-late stage trials exploring potential benefits in neurodegenerative disorders like Parkinsons disease