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How much intact peptide reaches systemic circulation by the oral route is genuinely uncertain, and any honest discussion has to say so

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Dosing schedules are based on the Phase 3 TRIUMPH clinical trial protocols

200-250 pounds (90-113kg): Consider 450-500mcg daily

AOD 9604 is typically given as a once-daily subcutaneous injection (under the skin)

Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted