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1 Introduction Renal diseases, particularly chronic kidney disease (CKD) and end-stage renal disease (ESRD), have emerged as major global public health challenges ( in vitro models that more accurately recapitulate the physiological and pathological processes of the human kidney, to facilitate mechanistic research, drug screening, and the exploration of alternative therapies
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Concerning CLICs, structures from three organisms, Caenorhabditis elegans , Drosophila melanogaster , and Homo sapiens are available (Harrop et al., 2001
Numerous in vitro and in vivo studies have demonstrated the ability of shiitake mushrooms to prevent or mitigate various diseases, enhance immune function, improve overall health, and potentially extend life expectancy
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