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A 2016 study showed that knuckle pigmentation is an external sign of a vitamin B-12 deficiency

Common side effects include nausea, diarrhoea, and a fishy body odour caused by trimethylamine production

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Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

Dysautonomia and POTS: The active Vitamin B6 (P-5-P) in the formula is required to synthesize GABA, an inhibitory neurotransmitter that helps calm the overactive sympathetic nervous system, potentially easing the rapid heart rate and adrenaline surges associated with dysautonomia

Primary Handling Editors: Yanina-Yasmin Pesch and Alfredo Gimenez-Cassina, in collaboration with the Nature Metabolism team