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When compared with the sodiumglucose cotransporter 2 (SGLT2) inhibitors group, the GLP-1RAs group showed no evidence of a difference in terms of new-onset heart failure (HR 0.97

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In conclusion, our study conducted within real-world clinical settings revealed a noteworthy association between the use of GLP-1 RAs, including Liraglutide and Semaglutide, and a heightened risk of psychiatric outcomes, encompassing depression, anxiety, and suicidal behaviour

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TL;DR Wegovy (semaglutide) is a GLP-1 receptor agonist weight loss injection that delivers 15-20% body weight loss , while Orlistat is a lipase inhibitor tablet that blocks fat absorption, achieving 4-8% weight loss

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