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The clinical implication is that intermittent pulsatile dosing, rather than multiple daily injections, is the strategy most consistent with preserving receptor sensitivity for either compound
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GSH-dependent mitochondrial functions are influenced by changes in levels of cytosolic GSH because GSH is synthesized in the cytosol and must be imported into the mitochondria to exert its function as antioxidant 122,123
GI symptom rates at the 12 mg dose included nausea (38-43%), diarrhea (33-35%), constipation (21-25%), and vomiting (20-21%)
July 2024
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