Symptoms typically emerge or worsen with dose escalation and generally improve over 4 to 8 weeks as tolerance develops
Tirzepatide carries a boxed warning regarding the risk of thyroid C-cell tumors, based on animal studies, though the relevance to humans remains uncertain
McGuire will present the findings during the Symposium Presentation: Effects of Oral Semaglutide on Cardiovascular (and Other) Outcomes in People with Type 2 Diabetes at High CV Risk Sunday, June 22 at 4:30 - 6:00 PM CT About the ADA's Scientific Sessions The ADA's 85th Scientific Sessions, the world's largest scientific meeting focused on diabetes research, prevention, and care, will be held in Chicago, IL on June 20-23
JAMA Cardiol
The much larger opportunity is preventing the downstream cascade: Type 2 diabetes, cardiovascular disease, fatty liver disease, kidney disease & perhaps even cognitive decline
doi:10.1056/NEJMoa2401943 20Chen VL, Morgan TR, Rotman Y, et al