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Phase I uses cytochrome P450 enzymes to alter toxins, which paradoxically often makes them temporarily more reactive and dangerous
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Before in vitro infection, PBMCs were rested overnight in the 24-well plate in a cell incubator at 37C with 5% CO 2
Gilbert DF, Boutros M
But an in-vitro permeability score is not the same as a measured oral bioavailability figure in an animal, and it is certainly not evidence of a human effect
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