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Conventional blood biomarkers like ALT and AST are released when hepatocytes die the damage has already been done, Zheng said
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10.1016/j.neuroscience.2007.08.028 110 Vzquez-MezaH.Vzquez-MezaH.Vilchis-LanderosM
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4.2 Liver cell model 4.2.1 Selection of hepatocytes Hepatocytes are the main cells responsible for drug metabolism in the liver, so they are used to construct an in vitro model to simulate liver function
Broad gene-mapping work led by Pickart and colleagues reported modulation of thousands of genes, with roughly a third of human gene patterns shifting toward expression states associated with younger or healthier tissue
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