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In some cases, temporarily reducing the dose or slowing the rate of dose escalation may be appropriate

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Semaglutide Start: 0.25 mg once weekly Increase to: 0.5 mg weekly Then: 1 mg weekly Maintenance: up to 1.72.4 mg weekly, depending on tolerance Tirzepatide Start: 2.5 mg once weekly Increase to: 5 mg weekly Then: 7.5 mg Then: 10 mg Then: 12.5 mg Maximum: 15 mg weekly Retatrutide (Currently follows dosing schedules used in clinical studies.) Start: 12 mg once weekly Gradually increase to: 4 mg Then: 8 mg Then: 12 mg weekly Your provider will determine the safest dose progression based on your response and tolerance

However, patients may notice darker yellow urine due to dehydration caused by the medication's common gastrointestinal effects, such as nausea, vomiting, or diarrhoea

Most patients achieved meaningful results (15-20% weight loss) at mid-range doses with better tolerability, supporting the case for gradual escalation rather than rushing to maximum dose