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J Neurol Sci 151:3539 Mandal PK, Shukla D, Tripathi M, Ersland L (2019) Cognitive Improvement with glutathione supplement in Alzheimer's disease: a way forward
PMID 12185074
"Affinity labeling of rat glutathione S -transferase isozyme 1-1 by 17-iodoacetoxy-estradiol-3-sulfate"
Interestingly, the authors attributed this effect to a lower energy intake rather than the macronutrient composition
When two compounds share a final therapeutic outcome (tissue repair) but achieve it through different receptors and cellular intermediaries, their combination can produce effects that exceed what either compound delivers alone without requiring dose escalation of either component
This work develops the first mathematical model for the GSH antioxidant system in the outer retina, capturing the most essential components for formation of ROS, GSH production, its oxidation in detoxifying ROS, and subsequent reduction by NADPH
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