This damage is caused by reactive metabolites that are generated by cytochrome P-450 liver enzymes, principally CYP2E1 ( 4 is administered repeatedly, it can cause hepato-centrilobular necrosis, inflammation, and activation of hepatic stellate cells
(3) Plasma GPx (GPx3) is present in the mitochondria of several organs, such as the kidney, lung, epididymis, breast, heart, and muscle
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This dramatically reduces the risk of hypoglycemia that plagues older sulfonylureas and insulin regimens
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