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In research it is best known for the way it works with amylin-family receptors, which sets it apart from the more common GLP-1 style peptides
11, 12 While these studies cant prove the drugs prevented dementia, they strongly suggest that GLP-1 drugs provide meaningful protection against cognitive decline
These drugs have also caused new or worsening kidney disease, including kidney failure, in some people
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Tirzepatide Research on naturally occurring incretins isolated from some fish (e.g., lamprey, dogfish and paddlefish) has shown that they can act as dual agonist of the GLP-1, GIP, and glucagon receptors, to lower blood glucose levels and induce weight loss (reviewed in Conlon et al., 2022)
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