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Tirzepatide acts as a dual GLP-1/GIP agonist, while retatrutide adds glucagon receptor agonism as a third target
10.1056/NEJMoa2401943 61 MaB.WangX.RenH.LiY.ZhangH.YangM.et al (2023)
The LEADER cardiovascular outcomes trial (N=9,340, median 3.8 years) showed liraglutide 1.8 mg reduced the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke by 13% versus placebo (hazard ratio 0.87
People experimenting with microdosing often attribute steadier energy levels to reduced medication intensity, although experiences vary from person to person
Thats because citrus fruits, tomatoes, vinegar, and certain beverages (like orange juice or carbonated drinks) can exacerbate gastrointestinal side effects like nausea, stomach discomfort, or acid reflux
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![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
