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Aging is one reason
Versus retinol and retinoic acid (cosmetic anti-ageing reference): retinol acts via RAR/RXR receptors and transcriptional modulation but with irritating effects (desquamation, solar sensitivity)
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The same mechanism that extends the replicative life of healthy cells also supports the proliferation of cancer cells, which are defined by their ability to bypass normal telomere-based growth limits
It functions as a post-translational modulator, participating in gene transcription, apoptosis, cell cycle regulation, metabolism, and development
Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Kelly DL, Cascella N, Fasano A
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