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doi: 10.1056/NEJMe2202547 123 IottiS.WolfF.MazurA.MaierJ
Myocardial lipid accumulation and lipotoxicity in heart failure
The cryo-EM structure shows that orforglipron stabilizes a unique conformation of TM1 and TM2 that differs from both the inactive receptor state and the peptide-bound active state
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