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There is maturation of the melanocytes with progressive descent into the dermis, which is analogous to that seen in acquired nevi

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Tirzepatide is a dual agonist targeting both GLP-1 and GIP receptors, while semaglutide targets only GLP-1

Lipid-Lowering Therapies Traditional lipid-lowering therapies statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, inclisiran, and bempedoic acid primarily reduce circulating apolipoprotein B (ApoB)containing lipoproteins, which both retards new atherogenesis and, at sufficient magnitude, drives angiographic plaque regression [15][17]

[19] [20] Reduced caloric intake , while intended for weight loss, can sometimes lead to insufficient energy consumption, particularly if patients are not eating nutrient-dense foods