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We verified the impact of ACTL6A on GSH synthesis and confirmed that ACTL6A KD led to reduced expression of certain genes (GCLC, GPX2, GPX4, SLC7A11, SLC1A5, GSS, GLS, etc.) involved in the GSH synthesis pathway (Supplementary Fig

10.1016/j.biopsych.2006.11.034 19 FanD.LiuL.WuZ.CaoM

(2014) in Current Chemical Biology highlighted GHK-Cus ability to silence copper(II) redox activity, preventing ROS formation and oxidative damage

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