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Demonstrated brain insulin resistance in Alzheimers disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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Excessive ROS could lead to the depolarization of IMM, the opening of mitochondrial permeability transition pore (mPTP), and the leakage of cytochrome c (Cytc) into the cytoplasm

European Journal of Gastroenterology & Hepatology , vol